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понедельник, 9 апреля 2012 г.

Effectiveness of inhaled corticosteroids for persons with early stages of asthma exacerbation


Inhaled corticosteroids are typically directed to cure persons with early asthma complications.
According to certain latest studies, one can increase the normal quantity of inhaled steroids by 8 times, but positive effects will be not enhanced in such situation. Ejaz Yousef, a doctor who has been involved in these studies, confirms that if a physician observes that medical position of a person worsens, he/she may recommend administering oral steroids instead of increasing the quantity of inhaled corticosteroids. Enhancing the dosage of inhaled corticosteroids is not without any negative symptom. This aspect leads to various adverse reactions. For example, the hypothalamic-pituitary adrenal axis may be suppressed in such situation.  
Application of inhaled corticosteroids was claimed to be alternative treatment to taking oral drugs. It was in 1997. It was recommended to indicate inhaled steroids as alternatives of oral medications that are effective in case of asthma exacerbations.
Then, several researches have manifested that application of enhanced doses of inhaled steroids systematically doesn’t enhance positive effects.
Yousef and his colleagues have conducted a study that involved almost 200 children of 2-17 years. These kids were treated with inhaled corticosteroids during 3 months. They were chosen randomly for treatment for a period of 12 days. Any kid who had asthma complications was given inhaled corticosteroids. Then the results were evaluated by the doctors.
No any kid who smoked, experienced symptoms of chronic asthma or lung pathology was involved in the study.
Patients needed to inform about their side results via telephone within 72 hours.  Thus, it was reported about cough during nighttime, wheeze, shortness of breath and intolerance  when it comes to exercises. Every result was evaluated according to a score which was ranged from 0 to 4. 0 meant no any sigh; 4 meant the most enhanced severity level.
Only 4 kids out of 82 the children that were given high measures of inhaled corticosteroids had to administer systemic corticosteroids. 2 of them were given doubled dosages; others two were applying the dosage that was more increased by 8 times than a typical one.
According to the results of the study, usefulness of the products, placebo effect, supervision of health care providers and treatment of individuals during early stages of asthma complications were responsible for obtaining positive results.
This as well as other studies demonstrate that not each story about steroids is connected with abuse and administration of them by sportspeople. Steroids are utilizable for numerous medical purposes.

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